Pseudoexfoliation syndrome and aneurysms of the abdominal aorta

Lancet. 2001 Feb 3;357(9253):359-60. doi: 10.1016/s0140-6736(00)03645-x.


We assessed the association between pseudoexfoliation syndrome, a common age-related fibrillopathy of unknown cause, and vascular diseases, especially aneurysms of the abdominal aorta. In a prospective single-blind study we ophthalmoscopically examined 55 patients with aneurysms of the abdominal aorta and 41 controls with carotic-artery occlusion. 24 of 55 patients with aortic aneurysm showed signs of manifest (17 of 55 patients) or early-stage (seven of 55) pseudoexfoliation syndrome. Eight of 41 control patients showed manifest (seven of 41 patients) and early (one of 41) ocular pseudoexfoliation (p=0.016). These findings, including histopathological examinations, suggest an association between aneurysms of the abdominal aorta and pseudoexfoliation syndrome.

Publication types

  • Letter

MeSH terms

  • Aged
  • Aortic Aneurysm, Abdominal / epidemiology*
  • Aortic Aneurysm, Abdominal / pathology
  • Case-Control Studies
  • Exfoliation Syndrome / epidemiology*
  • Exfoliation Syndrome / pathology
  • Female
  • Germany / epidemiology
  • Humans
  • Male
  • Prospective Studies
  • Single-Blind Method