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Case Reports
. 2000 Dec;49(4):347-8.

Pseudodementia in a Twenty-One-Year-Old With Bipolar Disorder and Vitamin B12 and Folate Deficiency

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  • PMID: 11211551
Case Reports

Pseudodementia in a Twenty-One-Year-Old With Bipolar Disorder and Vitamin B12 and Folate Deficiency

S D Reid. West Indian Med J. .

Abstract

A twenty-one-year-old female known to suffer from bipolar type I disorder developed features of a pseudodementia. Following prompt initial response to treatment with antidepressants, there was an early recurrence of cognitive impairment. Blood investigations confirmed a macrocytic anaemia and vitamin B12 and folate deficiencies. There was dramatic resolution of cognitive impairment after vitamin replacement. This suggested the occurrence of a reversible nutritional dementia and reinforced the need to rule out secondary organic causes of psychiatric symptoms even in patients previously diagnosed with a primary psychiatric disorder.

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