Three for T: molecular analysis of the low voltage-activated calcium channel family

Cell Mol Life Sci. 1999 Nov 15;56(7-8):660-9. doi: 10.1007/s000180050460.

Abstract

Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Channels, T-Type / chemistry
  • Calcium Channels, T-Type / genetics
  • Calcium Channels, T-Type / metabolism*
  • Cloning, Molecular
  • Electrophysiology
  • Evolution, Molecular
  • Gene Expression Profiling
  • Humans
  • Ion Channel Gating*
  • Phylogeny
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics

Substances

  • Calcium Channels, T-Type
  • RNA, Messenger