Effect of Dietary Fiber on the Activity of Intestinal and Fecal Beta-Glucuronidase Activity During 1,2-dimethylhydrazine Induced Colon Carcinogenesis

Plant Foods Hum Nutr. 2001;56(1):13-21. doi: 10.1023/a:1008188009174.


The effects of fiber isolated from black gram (Phaseolus mungo) and coconut (Cocos nucifera) kernel on the metabolic activity of intestinal and fecal beta glucuronidase activity during 1,2-dimethylhydrazine induced colon carcinogenesis were studied. The results indicated that the inclusion of fiber from black gram and coconut kernel generally supported lower specific activities and less fecal output of beta-glucuronidase than did the fiber free diet. This study suggests that the fibers isolated from coconut or black gram may potentially play a role in preventing the formation of colon tumors induced by the carcinogen 1,2-dimethylhydrazine by reducing the activity of the intestinal as well as fecal beta-glucuronidase.

MeSH terms

  • 1,2-Dimethylhydrazine / toxicity
  • Animals
  • Carcinogens / toxicity
  • Cocos / chemistry
  • Colonic Neoplasms / chemically induced
  • Colonic Neoplasms / enzymology*
  • Colonic Neoplasms / prevention & control
  • Dietary Fiber / pharmacology*
  • Feces / enzymology*
  • Glucuronidase / metabolism*
  • Intestines / enzymology*
  • Male
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors


  • Carcinogens
  • Dietary Fiber
  • Glucuronidase
  • 1,2-Dimethylhydrazine