FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties
- PMID: 11217798
- DOI: 10.7164/antibiotics.53.1341
FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties
Abstract
FR191512, a novel polyphenolic compound, inhibited the infectivity of influenza A virus in Madin-Darby canine kidney (MDCK) cells in vitro. Furthermore, FR191512 showed good in vivo anti-influenza activity in a mouse model of intranasal infection with influenza A virus. The cytotoxic activity of FR191512 against MDCK cells was very weak.
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