Translocation 4p-- syndrome: a general review

Am J Dis Child. 1975 Mar;129(3):366-70. doi: 10.1001/archpedi.1975.02120400066017.


The casee presented here may be the first fully identified and verified cas of translocation 4p-- syndrome, a B4/G22 translocation, ie, 45,XX,-4,-22,+t(4q 22q). Thirty-nine other cases of the 4p--syndrome, including one other possible translocation case, have been found in the medical literature. Conventional chromosome studies cannot distinguish between 4p-- (Wolf) syndrome and 5p-- (cri-du-chat) syndrome, and the clinical features, as in our case, may not be sufficiently characteristic to permit differentiation. The newer chromosome banding techniques have made specific identification possible.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Abnormalities, Multiple
  • Child, Preschool
  • Chromosome Aberrations* / diagnosis
  • Chromosome Disorders*
  • Chromosomes, Human, 4-5*
  • Cri-du-Chat Syndrome / diagnosis
  • Dermatoglyphics
  • Diagnosis, Differential
  • Female
  • Follow-Up Studies
  • Humans
  • Karyotyping / methods
  • Syndrome
  • Translocation, Genetic*