Localization of caveolin-1 in photoreceptor synaptic ribbons

Invest Ophthalmol Vis Sci. 2001 Mar;42(3):850-2.


Purpose: The purpose of this study is to determine whether caveolin-1 is a constituent of photoreceptor synaptic ribbons.

Methods: Immunoblot assay and electron microscopic immunocytochemistry were used to localize caveolin-1 in synaptic ribbons.

Results: Synaptic ribbons were localized close to the active site of presynaptic membranes and surrounded by a halo of synaptic vesicles. Immunosignals of caveolin-1 were clearly detected on the synaptic ribbons in rod and cone photoreceptors. However, the signal was seen neither on synaptic vesicles nor on presynaptic plasma membranes.

Conclusions: Caveolin-1 is a component protein of synaptic ribbons and may be involved in the regulation of transmitter release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Caveolin 1
  • Caveolins / analysis*
  • Electrophoresis, Polyacrylamide Gel
  • Eye Proteins / analysis*
  • Mice
  • Mice, Inbred BALB C
  • Microscopy, Immunoelectron
  • Photoreceptor Cells, Vertebrate / chemistry*
  • Presynaptic Terminals / chemistry*


  • Cav1 protein, mouse
  • Caveolin 1
  • Caveolins
  • Eye Proteins