Making decisions through Myc

FEBS Lett. 2001 Feb 16;490(3):153-62. doi: 10.1016/s0014-5793(01)02118-4.

Abstract

c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism
  • Cell Cycle* / genetics
  • Cell Division / genetics
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / metabolism
  • G1 Phase / genetics
  • Gene Expression Regulation
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism*
  • S Phase / genetics
  • Transcription, Genetic

Substances

  • Cell Cycle Proteins
  • Cyclins
  • Proto-Oncogene Proteins c-myc
  • Cyclin-Dependent Kinases