Peroxynitrite-mediated mitochondrial dysfunction

Biol Signals Recept. Jan-Apr 2001;10(1-2):66-80. doi: 10.1159/000046876.


Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function of mitochondrial proteins, leading to mitochondrial dysfunction and cellular or organ injury. These data are discussed along with its physiopathological implications.

Publication types

  • Review

MeSH terms

  • Energy Metabolism / drug effects
  • Mitochondria / drug effects
  • Mitochondria / physiology*
  • Nitrates / pharmacology*
  • Nitric Oxide / metabolism*
  • Oxidants / pharmacology*
  • Oxidative Stress*
  • Oxygen Consumption / drug effects


  • Nitrates
  • Oxidants
  • peroxynitric acid
  • Nitric Oxide