Anatomical substrates for neuroleptic-induced reward attenuation and neuroleptic-induced response decrement

Behav Pharmacol. 1991 Apr;2(2):129-141.


Rats were implanted with bilateral indwelling cannulae, in the nucleus accumbens (NAS), anterodorsal striatum (ADS) or basolateral amygdala (BLA). Administration of sulpiride to the NAS reduced spontaneous locomotion, caused a time-independent suppression of lever pressing on a random-interval 30sec schedule of food reinforcement, and reduced preference for a weak 0.7% sucrose solution over water without affecting the total volume of fluid consumed. Administration of sulpiride to the ADS did not affect spontaneous locomotion, but caused a time-dependent response decrement in both operant behaviour and consumption of 0.7% sucrose. Administration of sulpiride to the BLA had no effect in any of these tests. However, at all three infusion sites, sulpiride increased the consumption of a 34% sucrose solution. The data suggest a preferential involvement of the mesolimbic dopamine system in neurolepticinduced attenuation of reinforcer value, and a primary role of the nigrostriatal dopamine system in neuroleptic-induced time-dependent response decrements.