Treatment of paraphilia with luteinizing hormone-releasing hormone agonists

J Sex Marital Ther. Jan-Feb 2001;27(1):45-55. doi: 10.1080/00926230152035840.


Up to now there have been no published results of therapy of paraphilia (for example, pedophilia or sadism) and sexual aggressive impulsiveness with luteinizing hormone-releasing hormone (LHRH) agonists in the German-speaking countries. After a short introduction about physiologic features and the present state of investigations in treatment of paraphilia with LHRH agonists we describe 11 patients who were treated with the LHRH agonist Leuprolide Acetate over a period of 12 months. The patients showed no tendency toward sexually aggressive behavior and reported an evident reduction of penile erection, ejaculation, masturbation, sexually deviant impulsiveness, and fantasies. One patient died from suicide. In combination with other treatments, LHRH Agonists seem to be a very promising alternative to cyproterone acetate and its possible carcinogene effects.

MeSH terms

  • Adult
  • Androgen Antagonists / pharmacology
  • Androgen Antagonists / therapeutic use
  • Cyproterone / pharmacology
  • Cyproterone / therapeutic use
  • Gonadotropin-Releasing Hormone / metabolism*
  • Humans
  • Leuprolide / pharmacology*
  • Leuprolide / therapeutic use
  • Male
  • Middle Aged
  • Paraphilic Disorders / drug therapy*
  • Treatment Outcome


  • Androgen Antagonists
  • Gonadotropin-Releasing Hormone
  • Cyproterone
  • Leuprolide