Raised interleukin-6 levels in obese patients

Obes Res. 2000 Dec;8(9):673-5. doi: 10.1038/oby.2000.86.


Objective: Obese patients demonstrate a variety of biochemical, metabolic, and pulmonary abnormalities. Inflammatory mediators such as tumor necrosis factor-alpha and interleukin-6 (IL-6) may have a direct effect on glucose and lipid metabolism. Hypoxemia in itself induces release of IL-6. The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%).

Research methods and procedures: We measured serum IL-6 levels in 25 obese patients (body mass index of >35 kg/m2) and 12 healthy women.

Results: The results demonstrate statistically significant differences in serum IL-6 levels between the control group (1.28 +/- 0.85 pg/mL) and obese patients without OSAS (7.69 +/- 5.06 pg/mL, p < 0.05) and with OSAS (5.58 +/- 0.37 pg/mL, p < 0.0005). In the patients with OHS, IL-6 concentrations were highest (43.13 +/- 24.27 pg/mL).

Discussion: We conclude that serum IL-6 is increased in obese patients. The highest IL-6 levels were found in the patients with OHS.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Female
  • Humans
  • Hypoventilation / blood*
  • Hypoventilation / complications
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Obesity / blood*
  • Obesity / complications
  • Obesity / physiopathology
  • Oxygen Consumption / physiology
  • Sleep Apnea, Obstructive / blood*
  • Sleep Apnea, Obstructive / complications
  • Syndrome


  • Interleukin-6