Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity

Diabetes Obes Metab. 2000 Oct;2(5):323-5. doi: 10.1046/j.1463-1326.2000.00090.x.

Abstract

The aim of this study was to investigate the variations in the plasma levels of the soluble tumour necrosis factor receptor type-I (sTNFR-I) and type-II (sTNFR-II) during weight loss which was induced by 3 weeks on a very low calorie diet (3.9+/-0.1 MJ/day), in 17 non-diabetic obese women. Plasma sTNFR-I concentrations decreased significantly after weight loss (p < 0.05), but there was no significant change in plasma sTNFR-II. As the diet was associated with a significant decrease in body fat mass (=2.5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / blood*
  • Blood Glucose / analysis
  • Body Mass Index
  • Diet, Reducing*
  • Energy Intake
  • European Continental Ancestry Group
  • Female
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Middle Aged
  • Obesity / blood*
  • Obesity / physiopathology
  • Receptors, Tumor Necrosis Factor / blood*
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Weight Loss / physiology*

Substances

  • Antigens, CD
  • Blood Glucose
  • Insulin
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II