We present a new technique for minimal invasive radiological assisted necrosectomy (MIRAN) for infected necrosis in acute pancreatitis. We describe how to place volumic catheters for fragmentation and extraction of necrotic material. In addition a new technique is described for minimal invasive occlusion of selected pancreas tail to avoid fistulas. In 26 patients with infected necrosis of the pancreatic region, 12 patients (46.2%) could be healed by MIRAN alone. 5 patients (19.2%) could be satisfactory treated with a combination of MIRAN and operative necrosectomy. 9 patients (34.6%) died, 5 of them postoperatively. In 7 cases death followed multiple organ failure/dysfunction syndrome. 12 (71%) of 17 patients with the aim of curative treatment could be satisfactory treated with MIRAN. 2 other patients (12%) received additional surgery, 3 patients died (17%), 2 of them without any other treatment. The advantages of MIRAN are reduced trauma, general anaesthesia is not necessary, no difficult surgical preparation is necessary, no limits for additional therapy, reduced damage of neighbouring organs and vital pancreatic tissue as well as avoiding splenectomy.