Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

Curr Opin Immunol. 2001 Apr;13(2):147-53. doi: 10.1016/s0952-7915(00)00197-7.

Abstract

Upon exposure to IFN-gamma, the standard proteasome is replaced by the immunoproteasome, which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing antigenic peptides presented to CD8(+) T cells. This view has been challenged this year by reports showing that some epitopes, mainly of self origin, are not processed by the immunoproteasome and that mature dendritic cells constitutively express immunoproteasomes and therefore cannot efficiently present such epitopes.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm / immunology
  • Antigens, Neoplasm / metabolism
  • Cysteine Endopeptidases / immunology
  • Cysteine Endopeptidases / metabolism*
  • Epitopes, T-Lymphocyte / chemistry
  • Epitopes, T-Lymphocyte / immunology*
  • Epitopes, T-Lymphocyte / metabolism*
  • Gene Expression Profiling
  • Humans
  • Molecular Sequence Data
  • Multienzyme Complexes / immunology
  • Multienzyme Complexes / metabolism*
  • Proteasome Endopeptidase Complex
  • Protein Processing, Post-Translational
  • Proteins / immunology
  • Proteins / metabolism*

Substances

  • Antigens, Neoplasm
  • Epitopes, T-Lymphocyte
  • Multienzyme Complexes
  • Proteins
  • LMP-2 protein
  • Cysteine Endopeptidases
  • LMP7 protein
  • PSMB10 protein, human
  • Proteasome Endopeptidase Complex