Recognition of tumor cells by the innate immune system

Curr Opin Immunol. 2001 Apr;13(2):154-62. doi: 10.1016/s0952-7915(00)00198-9.


There has been a rapid increase in our understanding of the cellular components of the innate immune system, the receptors used to distinguish changes in homeostasis, and how these components integrate into an anti-tumor effector response. Recently, significant progress has been made in the identification of ligands for receptors that activate NK cells, and the results have implications for the recognition of tumor cells.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Cytotoxicity, Immunologic
  • Humans
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism
  • Membrane Proteins
  • Neoplasms / immunology*
  • Receptors, Immunologic / immunology*
  • Receptors, Immunologic / metabolism
  • Receptors, Natural Killer Cell
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism


  • Adaptor Proteins, Signal Transducing
  • Membrane Proteins
  • Receptors, Immunologic
  • Receptors, Natural Killer Cell
  • TYROBP protein, human