Chemokines in lymphopoiesis and lymphoid organ development

Curr Opin Immunol. 2001 Apr;13(2):172-9. doi: 10.1016/s0952-7915(00)00201-6.

Abstract

An important role has emerged for chemokines in regulating the distribution of progenitor cells during hematopoietic cell development. As well as recruiting cells, chemokines promote cell retention and cytokine expression. Furthermore, chemokines have been found to have an inductive function in secondary lymphoid organ development.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / metabolism
  • Chemokine CXCL12
  • Chemokines / metabolism*
  • Chemokines, CXC / metabolism
  • Embryonic Induction
  • Embryonic and Fetal Development
  • Humans
  • Lymphatic System / cytology
  • Lymphatic System / embryology*
  • Lymphatic System / metabolism*
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Thymus Gland / cytology
  • Thymus Gland / embryology
  • Thymus Gland / metabolism

Substances

  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines
  • Chemokines, CXC