Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

Bioorg Med Chem Lett. 2001 Feb 26;11(4):491-4. doi: 10.1016/s0960-894x(00)00702-2.


The NK1 and NK2 receptor activity of a series of 5-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl-1-piperidines was evaluated. Compounds 11d, 11e, 11f, 12a, and 12k were found to be our most potent inhibitors.

MeSH terms

  • Neurokinin-1 Receptor Antagonists*
  • Piperidines / chemical synthesis*
  • Piperidines / pharmacology
  • Receptors, Neurokinin-2 / antagonists & inhibitors*
  • Structure-Activity Relationship


  • Neurokinin-1 Receptor Antagonists
  • Piperidines
  • Receptors, Neurokinin-2