Lipoprotein lipase: physiology, biochemistry, and molecular biology

Front Biosci. 2001 Mar 1;6:D388-405. doi: 10.2741/goldberg.


Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / genetics
  • Humans
  • Lipoprotein Lipase / genetics
  • Lipoprotein Lipase / metabolism*
  • Lipoproteins / metabolism
  • Mutation
  • Triglycerides / metabolism


  • Lipoproteins
  • Triglycerides
  • Lipoprotein Lipase