Clathrin uncoating: Auxilin comes to life

Curr Biol. 2001 Jan 23;11(2):R49-52. doi: 10.1016/s0960-9822(01)00010-0.


The DnaJ protein auxilin has been extensively studied in vitro as a cofactor for uncoating clathrin-coated vesicles by the chaperone Hsc70. Recent studies provide the first evidence that auxilin plays this role in vivo, and work on a new mammalian auxilin suggests the protein may have more complex cellular functions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport
  • Amino Acid Sequence
  • Clathrin / physiology*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / physiology*
  • Phosphoproteins / chemistry
  • Phosphoproteins / physiology*
  • Sequence Homology, Amino Acid


  • Adaptor Proteins, Vesicular Transport
  • Clathrin
  • Nerve Tissue Proteins
  • Phosphoproteins