[Analgesia with oxygen-nitrous oxide mixture during percutaneous renal biopsy in children]

Arch Pediatr. 2001 Feb;8(2):145-9. doi: 10.1016/s0929-693x(00)00176-7.
[Article in French]


The efficacy of an inhaled equimolar mixture of nitrous oxide and oxygen (Entonox/MEOPA) to prevent procedural pain during renal percutaneous biopsies in children was assessed.

Patients and methods: One hundred and seven children who underwent 113 renal biopsies during a 17-month period were included in a prospective uncontrolled pediatric study. Efficacy was evaluated using patients' answers to a questionnaire and nurses' observations.

Results: Pain was absent in 86.5% of the cases. Mild adverse events were noted in one-third of the procedures, and were always reversible within a few minutes when the inhalation stopped. Acceptability was good. The use of this gas is easy and safe provided a few precautions are observed.

Conclusion: Inhaled equimolar mixture of nitrous oxide and oxygen prevents procedural pain during renal percutaneous biopsies.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Administration, Inhalation
  • Age Factors
  • Analgesia / adverse effects
  • Analgesia / methods*
  • Anesthetics, Combined / adverse effects
  • Anesthetics, Combined / chemistry
  • Anesthetics, Combined / therapeutic use*
  • Biopsy, Needle / adverse effects*
  • Chemistry, Pharmaceutical
  • Child
  • Dizziness / chemically induced
  • Female
  • Humans
  • Kidney Diseases / pathology*
  • Male
  • Nausea / chemically induced
  • Nitrous Oxide / adverse effects
  • Nitrous Oxide / chemistry
  • Nitrous Oxide / therapeutic use*
  • Oxygen / adverse effects
  • Oxygen / chemistry
  • Oxygen / therapeutic use*
  • Pain / diagnosis
  • Pain / drug therapy*
  • Pain / etiology*
  • Pain Measurement
  • Prospective Studies
  • Treatment Outcome
  • Vomiting / chemically induced


  • Anesthetics, Combined
  • Entonox
  • Nitrous Oxide
  • Oxygen