Biochemical profile of erythrocyte membrane of jaundiced neonates

Indian J Exp Biol. 2000 Jan;38(1):91-4.

Abstract

Studies in newborn humans have demonstrated alteration in the lipid, phospholipid and cholesterol content when compared with age-matched control. Membrane bound (Na+ + K+)ATPase activity is found to be significantly increased in jaundiced neonates. Alteration in membrane permeability characteristics in jaundiced neonates causes severe microenvironmental changes in red blood cell profile.

MeSH terms

  • Birth Weight
  • Cell Membrane Permeability
  • Cholesterol / blood
  • Enzyme Inhibitors / pharmacology
  • Erythrocyte Membrane / chemistry*
  • Erythrocyte Membrane / enzymology
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Jaundice, Neonatal / blood*
  • Male
  • Membrane Lipids / blood
  • Membrane Proteins / blood
  • Ouabain / pharmacology
  • Phospholipids / blood
  • Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors
  • Sodium-Potassium-Exchanging ATPase / blood

Substances

  • Enzyme Inhibitors
  • Membrane Lipids
  • Membrane Proteins
  • Phospholipids
  • Ouabain
  • Cholesterol
  • Sodium-Potassium-Exchanging ATPase