Infliximab for the Treatment of Orofacial Crohn's Disease

Inflamm Bowel Dis. 2001 Feb;7(1):38-42. doi: 10.1097/00054725-200102000-00006.


Orofacial manifestations of Crohn's disease can be difficult to diagnose and treat. We report a case in which the orofacial lesions occurred 7 years prior to the diagnosis of underlying inflammatory bowel disease. The patient was refractory to mesalamine and systemic corticosteroids but responded to infliximab, the chimeric monoclonal antibody to tumor necrosis factor (TNF-alpha). A review of the literature of the orofacial granulomatoses is presented as well.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Monoclonal / therapeutic use
  • Crohn Disease / complications*
  • Crohn Disease / diagnosis
  • Crohn Disease / drug therapy
  • Diagnosis, Differential
  • Face / pathology
  • Female
  • Gastrointestinal Agents / therapeutic use
  • Humans
  • Infliximab
  • Mouth / pathology
  • Skin Diseases / etiology*


  • Antibodies, Monoclonal
  • Gastrointestinal Agents
  • Infliximab