Ultrasonic depolymerization of the chitin-glucan complex from Aspergillus niger and antimutagenic activity of its product

Ultrason Sonochem. 1999 Mar;6(1-2):111-4. doi: 10.1016/s1350-4177(98)00024-8.

Abstract

Sonication was effective for the depolymerization of carboxymethylated chitin-glucan complex (CM-CG) isolated from the cell wall of Aspergillus niger. After 10 min of sonication and subsequent gel filtration, two samples (CM-CG(I) and CM CG(II)) with significantly distinct molecular weights (660 kDa and 19 kDa, respectively) and different nitrogen contents (3.02 and 1.69%) were obtained. CM-CG(II) with lower Mw was also effective against cyclophosphamide mutagenicity by oral administration in mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimutagenic Agents / chemical synthesis*
  • Antimutagenic Agents / pharmacology*
  • Aspergillus niger / chemistry*
  • Cell Wall / chemistry
  • Chemical Phenomena
  • Chemistry, Physical
  • Chitin / chemistry*
  • Chromatography, High Pressure Liquid
  • Cyclophosphamide / antagonists & inhibitors
  • Cyclophosphamide / toxicity
  • Female
  • Glucans / chemistry*
  • Mice
  • Mice, Inbred ICR
  • Mutagens / toxicity
  • Ultrafiltration
  • Ultrasonics

Substances

  • Antimutagenic Agents
  • Glucans
  • Mutagens
  • Chitin
  • Cyclophosphamide