[Antibacterial activity of urine after administration of ofloxacin for 5 days]

Therapie. 2000 Nov-Dec;55(6):691-7.
[Article in French]

Abstract

The antibacterial activity of ofloxacin was evaluated in urine over a period of 96 h after oral administration for 5 days of 200 mg twice a day in 12 healthy female volunteers. Bacteriostatic and bactericidal activity of urines were studied for five strains of enterobacterias recovered from urinary infections: two strains of Escherichia Coli Nal-S and Nal-R, two strains of Proteus mirabilis Nal-S and Nal-R, and one strain of Klebsiella pneumoniae Nal-S. Mean urinary concentrations of ofloxacin were very high during the first 12 h following last intake. They were still above 7 mg/l till the 48th hour and above 1.6 mg/l till the 72nd hour. Bactericidal activity of urine was present for 72 h in respect of four strains studied at that time; urine was not bactericidal as regards E. coli Nal-R. After 5 days of oral treatment with ofloxacin (200 mg b.i.d.), urine retains a bactericidal activity for at least 72 h against bacterial strains of urinary tract infections.

MeSH terms

  • Anti-Infective Agents, Urinary / administration & dosage
  • Anti-Infective Agents, Urinary / urine*
  • Escherichia coli / growth & development
  • Escherichia coli / isolation & purification
  • Female
  • Humans
  • Klebsiella pneumoniae / growth & development
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • Ofloxacin / administration & dosage
  • Ofloxacin / blood
  • Ofloxacin / urine*
  • Proteus mirabilis / growth & development
  • Proteus mirabilis / isolation & purification
  • Time Factors
  • Urinary Tract Infections / microbiology*
  • Urinary Tract Infections / urine

Substances

  • Anti-Infective Agents, Urinary
  • Ofloxacin