Abstract
We describe the case of an aspirin-sensitive asthma patient with a history of anaphylactic reactions to nonsteroidal anti-inflammatory drugs. The patient was subsequently diagnosed with rheumatoid arthritis and treated with a cyclooxygenase (COX)-2 inhibitor without an adverse response. Current prescribing information warns to avoid using COX-2 inhibitors in aspirin-sensitive asthma patients. New evidence suggests that aspirin sensitivity may be linked to the COX-1 pathway, and COX-2 inhibitors, as a result of their selectivity, may be beneficial in patients with aspirin-induced asthma.
MeSH terms
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Aged
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Anaphylaxis / chemically induced
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arthritis, Rheumatoid / drug therapy
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Aspirin / adverse effects*
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Asthma / chemically induced*
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Celecoxib
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / therapeutic use*
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Female
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Humans
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Isoenzymes / antagonists & inhibitors*
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Membrane Proteins
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Prostaglandin-Endoperoxide Synthases
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Pyrazoles
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Sulfonamides / therapeutic use*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Membrane Proteins
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Pyrazoles
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Sulfonamides
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Cyclooxygenase 2
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases
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Celecoxib
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Aspirin