Interindividual variations in beliefs about the placebo effect: a study in 300 rheumatology inpatients and 100 nurses

Joint Bone Spine. 2001 Feb;68(1):65-70. doi: 10.1016/s1297-319x(00)00225-6.


Patients and methods: Three hundred patients admitted to a rheumatology department (mean age, 49.2+/-15.5 years) and 100 nurses working in the same teaching hospital (mean age, 36+/-8.6 years) completed a questionnaire on the placebo effect in the treatment of pain.

Results: The patients believed that the percentages of subjects who responded occasionally or consistently to a placebo were 32% (+/- 22%) and 21% (+/- 17%), respectively. The figures given by the nurses were only slightly higher: 42% (+/- 23%) and 23% (+/- 17%), respectively. Only 27% of the patients and 58% of the nurses knew that pain could resolve completely under placebo therapy. The mean percentage improvement induced by placebo therapy as compared to the study analgesic was estimated at 21% (+/- 17%) by the patients and 30% (+/- 18%) by the nurses. Only 23% of patients and 24% of nurses knew about nocebo effects.

Conclusion: These data suggest that during double-blind placebo-controlled trials three-quarters of the placebo arm patients who experience a marked improvement or a nocebo effect may believe they received the active drug. This is likely to reduce the difference between the placebo and active drug groups. Furthermore, most patients and nurses have a negative perception of placebo therapy. It may be useful to include a brief description of placebo and nocebo effects into the patient's information and informed consent documents used in double-blind placebo-controlled trials.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Female
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Low Back Pain / therapy*
  • Male
  • Middle Aged
  • Nurses / psychology*
  • Patients / psychology*
  • Placebo Effect*
  • Rheumatic Diseases / psychology*
  • Rheumatic Diseases / therapy*
  • Surveys and Questionnaires