Antidepressant-associated mania and psychosis resulting in psychiatric admissions

J Clin Psychiatry. 2001 Jan;62(1):30-3. doi: 10.4088/jcp.v62n0107.

Abstract

Background: The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs.

Method: All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed.

Results: Forty-three (8.1%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis.

Conclusion: Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Antidepressive Agents / adverse effects*
  • Antidepressive Agents / therapeutic use
  • Antidepressive Agents, Tricyclic / adverse effects
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Bipolar Disorder / chemically induced*
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / epidemiology
  • Connecticut / epidemiology
  • Female
  • Hospitalization / statistics & numerical data*
  • Humans
  • Male
  • Mental Disorders / drug therapy
  • Mental Disorders / psychology
  • Middle Aged
  • Psychiatric Department, Hospital / statistics & numerical data
  • Psychoses, Substance-Induced / diagnosis
  • Psychoses, Substance-Induced / epidemiology
  • Psychoses, Substance-Induced / etiology*
  • Retrospective Studies
  • Serotonin Uptake Inhibitors / adverse effects
  • Serotonin Uptake Inhibitors / therapeutic use

Substances

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Serotonin Uptake Inhibitors