Effect of the Herbicide Glyphosate on Enzymatic Activity in Pregnant Rats and Their Fetuses

Environ Res. 2001 Mar;85(3):226-31. doi: 10.1006/enrs.2000.4229.


To prevent health risk from environmental chemicals, particularly for progeny, we have studied the effects of the herbicide glyphosate on several enzymes of pregnant rats. Glyphosate is an organophosphorated nonselective agrochemical widely used in many countries including Argentina and acts after the sprout in a systemic way. We have studied three cytosolic enzymes: isocitrate dehydrogenase-NADP dependent, glucose-6-phosphate dehydrogenase, and malic dehydrogenase in liver, heart, and brain of pregnant Wistar rats. The treatment was administered during the 21 days of pregnancy, with 1 week as an acclimation period. The results suggest that maternal exposure to agrochemicals during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / enzymology
  • Female
  • Fetus / drug effects*
  • Glucosephosphate Dehydrogenase / metabolism*
  • Glycine / analogs & derivatives*
  • Glycine / toxicity*
  • Herbicides / toxicity*
  • Isocitrate Dehydrogenase / metabolism*
  • Liver / drug effects
  • Liver / enzymology
  • Malate Dehydrogenase / metabolism*
  • Myocardium / enzymology
  • Pregnancy
  • Rats


  • Herbicides
  • glyphosate
  • Malate Dehydrogenase
  • Isocitrate Dehydrogenase
  • Glucosephosphate Dehydrogenase
  • Glycine