Secretion of trophic gut peptides is not different in bolus- and continuously fed piglets

J Nutr. 2001 Mar;131(3):729-32. doi: 10.1093/jn/131.3.729.


In neonates, bolus feeding is associated with greater rates of intestinal growth than is continuous feeding. We tested whether the concentrations and secretion rates of trophic gut peptides are higher in bolus-fed than in continuously fed piglets. Five 21-d-old piglets were surgically implanted with gastric, arterial and portal catheters and a portal blood flow probe. At postnatal d 30 and 31, pigs received an equal amount of primed continuous or bolus feeding of a cow's milk formula in a randomized, crossover design. During a 6-h period, portal blood flow and arterial and portal concentrations of glucagon-like peptide-2 (GLP-2), peptide YY (PYY) and gastric inhibitory polypeptide (GIP) were measured. All hormone levels were significantly increased within 1 h of the start of the experiment, independent of the feeding modality. There were no differences between bolus and continuous feeding in either the arterial concentrations or secretion rates of GLP-2, PYY and GIP. In both treatment groups, the increases in the plasma concentrations of GLP-2 and GIP after feeding were substantially greater than those for PYY. We conclude that the production or circulating concentrations of GLP-2, PYY and GIP are not significantly different in bolus- and primed continuously fed piglets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Flow Velocity
  • Catheterization
  • Cross-Over Studies
  • Digestive System / growth & development
  • Digestive System / metabolism*
  • Feeding Methods*
  • Gastric Inhibitory Polypeptide / metabolism
  • Gastrointestinal Hormones / metabolism*
  • Glucagon-Like Peptide 2
  • Glucagon-Like Peptides
  • Peptide YY / metabolism
  • Peptides / metabolism*
  • Portal System / physiology
  • Random Allocation
  • Swine


  • Gastrointestinal Hormones
  • Glucagon-Like Peptide 2
  • Peptides
  • Peptide YY
  • Gastric Inhibitory Polypeptide
  • Glucagon-Like Peptides