L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats

J Nutr. 2001 Mar;131(3):796-9. doi: 10.1093/jn/131.3.796.

Abstract

L-Arabinose is a natural, poorly absorbed pentose that selectively inhibits intestinal sucrase activity. To investigate the effects of L-arabinose feeding on lipogenesis due to its inhibition of sucrase, rats were fed 0-30 g sucrose/100 g diets containing 0-1 g L-arabinose/100 g for 10 d. Lipogenic enzyme activities and triacylglycerol concentrations in the liver were significantly increased by dietary sucrose, and arabinose significantly prevented these increases. Arabinose feeding reduced the weights of epididymal adipose tissue. Moreover, plasma insulin and triacylglycerol concentrations were significantly reduced by dietary L-arabinose. These findings suggest that L-arabinose inhibits intestinal sucrase activity, thereby reducing sucrose utilization, and consequently decreasing lipogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Citrate (pro-S)-Lyase / antagonists & inhibitors
  • ATP Citrate (pro-S)-Lyase / metabolism
  • Acetyl-CoA Carboxylase / antagonists & inhibitors
  • Acetyl-CoA Carboxylase / metabolism
  • Adipose Tissue / drug effects
  • Animals
  • Arabinose / administration & dosage
  • Arabinose / pharmacology*
  • Blood Glucose / analysis
  • Dietary Sucrose / administration & dosage*
  • Dietary Sucrose / metabolism
  • Fatty Acid Synthases / antagonists & inhibitors
  • Fatty Acid Synthases / metabolism
  • Insulin / blood
  • Intestinal Absorption / drug effects
  • Intestinal Mucosa / enzymology*
  • Liver / enzymology
  • Liver / metabolism*
  • Male
  • Rats
  • Rats, Wistar
  • Sucrase / antagonists & inhibitors*
  • Sucrase / metabolism
  • Triglycerides / blood
  • Triglycerides / metabolism*

Substances

  • Blood Glucose
  • Dietary Sucrose
  • Insulin
  • Triglycerides
  • Arabinose
  • Fatty Acid Synthases
  • ATP Citrate (pro-S)-Lyase
  • Sucrase
  • Acetyl-CoA Carboxylase