Tbr1 regulates differentiation of the preplate and layer 6

Neuron. 2001 Feb;29(2):353-66. doi: 10.1016/s0896-6273(01)00211-2.


During corticogenesis, early-born neurons of the preplate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Adhesion Molecules, Neuronal / metabolism*
  • Cell Death
  • Cell Movement / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Extracellular Matrix Proteins / metabolism*
  • Gene Expression Regulation, Developmental / physiology*
  • Germ Layers / metabolism*
  • Lac Operon / physiology
  • Mice
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Mutation
  • Neocortex / abnormalities
  • Neocortex / embryology*
  • Neocortex / growth & development
  • Nerve Tissue Proteins
  • Neural Pathways / physiology
  • Neurons / metabolism
  • Reelin Protein
  • Serine Endopeptidases
  • Synaptic Transmission
  • T-Box Domain Proteins


  • Cell Adhesion Molecules, Neuronal
  • DNA-Binding Proteins
  • Extracellular Matrix Proteins
  • Nerve Tissue Proteins
  • Reelin Protein
  • T-Box Domain Proteins
  • Tbr1 protein, mouse
  • Reln protein, mouse
  • Serine Endopeptidases