Epithelial and stromal syndecan-1 expression as predictor of outcome in patients with gastric cancer

Int J Cancer. 2001 Jan 20;95(1):1-6. doi: 10.1002/1097-0215(20010120)95:1<1::aid-ijc1000>3.0.co;2-5.


The prognostic value of the immunohistochemical expression of epithelial and stromal syndecan-1 was evaluated in 296 patients with gastric carcinoma. Formalin-fixed, paraffin-embedded specimens of gastric adenocarcinomas were stained with mouse monoclonal antibody B-B4 against human syndecan-1. Loss of immunoreactivity (syndecan-1 immunoreactivity correlated with a higher stage of disease (stages II-IV), tumour location in the upper third of the stomach, nodal metastases (N1 or N2), positive stromal syndecan-1 staining, deep tumour penetration (to subserosa or deeper = T2-T4), larger tumour size (> or = 5 cm) and intestinal type of cancer. No correlation between epithelial syndecan-1 immunoreactivity and age, gender, distant metastases, grade of differentiation or Borrmann classification was observed. Positive stromal syndecan-1 immunoreactivity correlated with decreased epithelial syndecan-1 expression, intestinal type of cancer and Borrmann type I. Patients with low epithelial syndecan-1 expression in cancer cells had worse overall survival than patients with strong epithelial syndecan-1 staining (p = 0.0012). Stromal syndecan-1-positive patients had a worse outcome than patients with syndecan-1-negative stroma (p = 0.0193). In Cox multivariate analysis, stromal syndecan-1 immunoreactivity was a prognostic factor independent of TNM stage, surgery for cure and tumour size. Thus, the immunohistochemical expression of syndecan-1 might be a predictor of outcome in patients with gastric adenocarcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / metabolism
  • Adenocarcinoma / mortality
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Animals
  • Antibodies, Monoclonal / metabolism
  • Disease Progression
  • Epithelium / metabolism*
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis
  • Male
  • Membrane Glycoproteins / biosynthesis*
  • Mice
  • Middle Aged
  • Multivariate Analysis
  • Prognosis
  • Proteoglycans / biosynthesis*
  • Sex Factors
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / therapy*
  • Stromal Cells / metabolism*
  • Syndecan-1
  • Syndecans
  • Time Factors
  • Treatment Outcome


  • Antibodies, Monoclonal
  • Membrane Glycoproteins
  • Proteoglycans
  • SDC1 protein, human
  • Sdc1 protein, mouse
  • Syndecan-1
  • Syndecans