Lumbar puncture in pediatric oncology: conscious sedation vs. general anesthesia

Med Pediatr Oncol. 2001 Mar;36(3):372-9. doi: 10.1002/mpo.1088.


Background: Lumbar punctures (LP) generally have been performed with conscious sedation (CS) but are increasingly performed using general anesthesia (GA) owing to the belief that this is less distressing. The aim of this study was to compare these two methods concerning distress, discomfort, pain, well-being and security after the LP, and problems with the LP.

Procedure: Twenty-five children with cancer participated in this prospective, randomized, crossover study. Children, parents, and nurses completed a visual analogue scale questionnaire to evaluate the efficacy of CS and GA. In addition, sedation and anesthesia protocols were reviewed.

Results: The two methods seemed to be equivalent concerning distress, discomfort, pain, well-being and security after the procedure, and procedure problems. Most children (80%), parents (66%), and nurses (58%) preferred LP in CS. However, the LP was not performed in CS in five cases because the child did not cooperate. Younger children less often preferred CS.

Conclusions: Outcomes for CS and GA in LP were similar. Although there were failures with the CS model, most preferred it to GA. LP in CS also saved time and medical resources. An alternative approach would be to have a pediatric anesthesiologist available at the oncology ward for these elective LPs to provide the sedation or anesthesia required by each individual.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anesthesia, General*
  • Antineoplastic Agents / administration & dosage
  • Anxiety / prevention & control
  • Child
  • Child, Hospitalized / psychology*
  • Child, Preschool
  • Conscious Sedation*
  • Cross-Over Studies
  • Female
  • Humans
  • Infant
  • Injections, Spinal
  • Leukemia / drug therapy
  • Lymphoma / drug therapy
  • Male
  • Pain / prevention & control*
  • Pain Measurement
  • Prospective Studies
  • Spinal Puncture*
  • Surveys and Questionnaires
  • Treatment Outcome


  • Antineoplastic Agents