Creutzfeldt-Jakob disease: serial changes on diffusion-weighted MRI

J Comput Assist Tomogr. 2001 Mar-Apr;25(2):274-7. doi: 10.1097/00004728-200103000-00022.


We present serial changes on diffusion-weighted MRI (DWI) in a patient with Creutzfeldt-Jakob disease (CJD). DWI revealed serial changes of abnormal hyperintense lesions that had become more extensive and conspicuous with progression of neurologic findings, more sensitively than conventional MRI. In the late stage, disappearance of abnormal hyperintense lesions on DWI was observed. DWI proved to be particularly useful for monitoring the progression of CJD.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Brain / pathology*
  • Creutzfeldt-Jakob Syndrome / diagnosis*
  • Creutzfeldt-Jakob Syndrome / pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging*