Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme

Br J Nutr. 2000 Nov;84 Suppl 1:S33-7. doi: 10.1017/s0007114500002221.


Numerous casein and whey protein-derived angiotensin-I-converting enzyme (ACE) inhibitory peptides/hydrolysates have been identified. Clinical trials in hypertensive animals and humans show that these peptides/hydrolysates can bring about a significant reduction in hypertension. These peptides/hydrolysates may be classified as functional food ingredients and nutraceuticals due to their ability to provide health benefits i.e. as functional food ingredients in reducing the risk of developing a disease and as nutraceuticals in the prevention/treatment of disease.

Publication types

  • Review

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / chemistry
  • Angiotensin-Converting Enzyme Inhibitors / metabolism*
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Animals
  • Biological Products / therapeutic use
  • Dietary Supplements
  • Food
  • Humans
  • Hypertension / therapy*
  • Mammals / physiology
  • Milk Proteins / chemistry
  • Milk Proteins / metabolism*
  • Peptidyl-Dipeptidase A / metabolism
  • Peptidyl-Dipeptidase A / physiology


  • Angiotensin-Converting Enzyme Inhibitors
  • Biological Products
  • Milk Proteins
  • Peptidyl-Dipeptidase A