Chemokine receptor desensitization in tumor-bearing mice

Cell Immunol. 2001 Feb 1;207(2):81-8. doi: 10.1006/cimm.2000.1754.


We found that the murine breast cancer cell line 4T1 constitutively produced several chemokines capable of recruiting T cells. Additionally, supernatants from the tumor cell line mediated chemotaxis of T cells in a pertussis toxin-sensitive manner, indicating that these chemokines were functional. However, we also found an impaired chemotactic ability of splenic T cells in mice bearing these same tumors. The receptors for RANTES, MCP-1, and SLC were desensitized. Thus, the impaired chemotactic ability of T cells in tumor-bearing mice may explain why tumors that secrete chemokines grow progressively in a host.

MeSH terms

  • Animals
  • Chemotaxis, Leukocyte
  • Mice
  • Mice, Inbred BALB C
  • Neoplasms, Experimental / immunology*
  • Receptors, Chemokine / analysis
  • Receptors, Chemokine / physiology*
  • T-Lymphocytes / immunology


  • Receptors, Chemokine