Role of T antigen interactions with p53 in tumorigenesis

Semin Cancer Biol. 2001 Feb;11(1):23-30. doi: 10.1006/scbi.2000.0343.

Abstract

SV40 induces neoplastic transformation by disabling several key cellular growth regulatory circuits. Among these are the Rb- and p53-families of tumor suppressors. The multifunctional, virus-encoded large T antigen blocks the function of both Rb and p53. Large T antigen uses multiple mechanisms to block p53 activity, and this action contributes to tumorigenesis, in part, by blocking p53-mediated growth suppression and apoptosis. Since the p53 pathway is inactivated in most human tumors, T antigen/p53 interactions offer a possible mechanism by which SV40 contributes to human cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Polyomavirus Transforming / physiology*
  • Cell Division
  • Cell Transformation, Neoplastic
  • DNA Tumor Viruses / physiology*
  • Mice
  • Mice, Knockout
  • Neoplasms / metabolism*
  • Protein Binding
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism*
  • Transcriptional Activation
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Antigens, Polyomavirus Transforming
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53