Cross-presentation, dendritic cells, tolerance and immunity

Annu Rev Immunol. 2001;19:47-64. doi: 10.1146/annurev.immunol.19.1.47.


This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Dendritic Cells / immunology*
  • HLA Antigens / immunology
  • Histocompatibility Antigens / immunology
  • Humans
  • Immune Tolerance / immunology*
  • Immunity / immunology*
  • Macrophages / immunology
  • Mice
  • Mice, Transgenic
  • T-Lymphocyte Subsets / immunology


  • HLA Antigens
  • Histocompatibility Antigens