Comparison of hypotonic and isotonic solutions containing sodium hyaluronate on the symptomatic treatment of dry eye patients

Ophthalmologica. 2001 Mar-Apr;215(2):124-7. doi: 10.1159/000050842.


This study was designed to compare the efficacy of two artificial tears both containing hyaluronic acid but differing in their osmolarity. A multicentric double-masked, crossover clinical trial was performed in which 158 subjects were randomized to receive either hypotonic or isotonic artificial tears up to 6 times a day. Both treatments were effective in improving signs and symptoms to a similar extent. No adverse events were reported. It was concluded that hypotonic and isotonic eye drops are comparable for the symptomatic treatment of patients suffering from dry eye syndrome.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Cross-Over Studies
  • Double-Blind Method
  • Dry Eye Syndromes / drug therapy*
  • Dry Eye Syndromes / physiopathology
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / adverse effects
  • Hypotonic Solutions
  • Isotonic Solutions
  • Ophthalmic Solutions / administration & dosage*
  • Ophthalmic Solutions / adverse effects
  • Osmolar Concentration
  • Tears / physiology
  • Treatment Outcome


  • Hypotonic Solutions
  • Isotonic Solutions
  • Ophthalmic Solutions
  • Hyaluronic Acid