Epstein-Barr virus-related lymphoproliferative disease complicating childhood acute lymphoblastic leukemia: no recurrence after unrelated donor bone marrow transplantation

Bone Marrow Transplant. 2001 Jan;27(1):93-5. doi: 10.1038/sj.bmt.1702727.


A 16-year-old boy in complete remission of ALL, undergoing oral maintenance therapy, developed intestinal perforation related to EBV-associated lymphoproliferative disease (LPD). He was successfully managed with surgical resection, acyclovir, immunoglobulins and discontinuation of maintenance therapy. Leukemic marrow relapse occurred 3 months later, treated by polychemotherapy followed by unmanipulated BMT from a matched unrelated EBV seropositive donor. Donor lymphocytes were infused twice after transplant because of delayed immunologic recovery and severe CMV colitis. This was followed by acute GVHD requiring prolonged immunosuppressive treatment. Despite intensive and prolonged immunosuppression, recurrence of LPD was not observed. Following EBV-related LPD, allogeneic BMT can be performed if indicated. Selection of an EBV seropositive donor is of major importance for the prevention of LPD recurrence as the recipient may be protected by passive transfer of EBV-specific cytotoxic T cells.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Blood Donors
  • Bone Marrow Transplantation / methods
  • Herpesvirus 4, Human*
  • Humans
  • Lymphocyte Transfusion
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / therapy
  • Lymphoproliferative Disorders / virology*
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Secondary Prevention
  • Transplantation, Homologous / methods