Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats

Zhongguo Yao Li Xue Bao. 1999 Sep;20(9):813-8.


Aim: The effects of modafinil and amphetamine on sleep-wake cycle and cortical power spectrum were assessed in the cats before and after sleep deprivation.

Methods: The sleep deprivation in the cats was used with the water tank technique. Cats were administrated with modafinil (5 mg.kg-1 p.o.) or amphetamine (1 mg.kg-1) before and after sleep deprivation.

Results: The waking effect of 8-10 h induced by modafinil before and after sleep deprivation was similar and was not followed by an increase in sleep rebound. On the contrary, the arousal effect about 8 h evoked by amphetamine after sleep deprivation was less lasting than that of 10-12 h observed in normal conditions and followed by an amplified rebound in both deep slow wave sleep and paradoxical sleep.

Conclusion: These results suggest the efficiency of modafinil against somnolence and hypersomnia without increasing subsequent sleep.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine / pharmacology
  • Animals
  • Benzhydryl Compounds / pharmacology*
  • Cats
  • Central Nervous System Stimulants / pharmacology*
  • Electroencephalography
  • Electromyography
  • Electrooculography
  • Female
  • Male
  • Modafinil
  • Sleep / drug effects*
  • Sleep Deprivation / physiopathology*
  • Wakefulness / drug effects*


  • Benzhydryl Compounds
  • Central Nervous System Stimulants
  • Amphetamine
  • Modafinil