Utility of Tc-99m GSA whole-body scintigraphy in detecting bone metastases from hepatocellular carcinoma

Clin Nucl Med. 2001 Mar;26(3):221-4. doi: 10.1097/00003072-200103000-00008.


Recent advances in the treatment of hepatocellular carcinoma (HCC) have prolonged patient survival. However, the number of patients with bone metastases identified during follow-up examinations has increased. Tc-99m Sn-N-pyridoxy-5-methyltryptophan (Tc-99m PMT) has been reported to accumulate at a high rate in HCC lesions and bone metastases. In the patient described here, whole-body scintigraphy showed accumulation of DTPA galactosyl human serum albumin (Tc-99m GSA) and Tc-99m PMT in bone metastases from HCC. The authors suggest that asialoglycoprotein receptors may be present in bone metastases from well-differentiated HCC. Tc-99m GSA whole-body imaging can be used to detect bone metastases from HCC and to evaluate hepatic reserve.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Albumins*
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / secondary*
  • Carcinoma, Hepatocellular / diagnostic imaging*
  • Carcinoma, Hepatocellular / secondary*
  • Humans
  • Liver Neoplasms / pathology*
  • Male
  • Middle Aged
  • Organotechnetium Compounds*
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Technetium Tc 99m Medronate / analogs & derivatives*
  • Tryptophan / analogs & derivatives*


  • Albumins
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m (Sn)-N-pyridoxyl-5-methyltryptophan
  • technetium Tc 99m neogalactoalbumin
  • technetium Tc 99m hydroxymethylene diphosphonate
  • Tryptophan
  • Technetium Tc 99m Medronate