Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism

Cancer Res. 2001 Feb 15;61(4):1296-8.

Abstract

The matrix metalloproteinases (MMPs) are implicated in connective tissue destruction during cancer invasion and metastasis. A naturally occurring variant arising from the insertion or deletion of a guanine in the promoter of the MMP-1 gene has recently been reported and shown to influence its transcriptional activity in melanoma cells. In this study, MMP-1 genotype was determined in 139 Caucasian patients with cutaneous malignant melanoma. The insertion allele was associated with deep invasive, and therefore poorer-prognosis, primary tumors [(34% of patients with vertical growth phase tumor were homozygous for the insertion allele compared with 17% of patients with horizontal growth phase tumor (P = 0.0333; odds ratio = 2.51)]. These data suggest that the invasiveness of cutaneous malignant melanoma is influenced by variation in the MMP-1 gene promoter that affects MMP-1 expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Division / genetics
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Matrix Metalloproteinase 1 / genetics*
  • Melanoma / genetics*
  • Melanoma / pathology*
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology
  • Polymorphism, Genetic*
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology*
  • White People / genetics

Substances

  • Matrix Metalloproteinase 1