DDT -- a novel domain in different transcription and chromosome remodeling factors

Trends Biochem Sci. 2001 Mar;26(3):145-6. doi: 10.1016/s0968-0004(00)01769-2.


Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.

MeSH terms

  • Amino Acid Sequence
  • Chromosomes*
  • Homeodomain Proteins / chemistry
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry*


  • Homeodomain Proteins
  • Transcription Factors