The protease-associated domain: a homology domain associated with multiple classes of proteases

Trends Biochem Sci. 2001 Mar;26(3):147-8. doi: 10.1016/s0968-0004(00)01768-0.


The non-catalytic part of proteases frequently harbours domains responsible for regulation or targeting. Here, we describe a novel sequence motif conserved in proteins that belong to different protease superfamilies, the subtilases and Zn-containing metalloproteases. The structure of the transferrin receptor, a catalytically inactive member of the latter family, suggests that the protease-associated domain forms a lid structure that covers the active site. In addition to proteases, the domain is also found in two different families of plant vacuolar sorting receptors.

MeSH terms

  • Amino Acid Sequence
  • Catalytic Domain
  • Endopeptidases / chemistry*
  • Endopeptidases / metabolism
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • Endopeptidases