I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations

Trends Biochem Sci. 2001 Mar;26(3):186-90. doi: 10.1016/s0968-0004(00)01753-9.


Activation of the transcription factor nuclear factor kappa B (NF-kappa B) requires its release from inhibitor of NF-kappa B (I kappa B) proteins in the cytoplasm. Much work has focussed on the identification of pathways regulating this cytosolic rate-limiting step of NF-kappa B activation. However, there is increasing evidence for another complex level of NF-kappa B activation, which involves modulatory phosphorylations of the DNA-binding subunits. These phosphorylations can control several functions of NF-kappa B, including DNA binding and transactivation properties, as well as interactions between the transcription factor and regulatory proteins. Although their overall impact on NF-kappa B function has yet to be determined, modifications of this factor will very probably provide a mechanism to fine tune NF-kappa B function.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • DNA / metabolism
  • I-kappa B Proteins / metabolism*
  • NF-kappa B / metabolism*
  • Phosphorylation
  • Signal Transduction
  • Transcriptional Activation


  • I-kappa B Proteins
  • NF-kappa B
  • DNA