[Ozone therapy of migraine]

Zh Nevrol Psikhiatr Im S S Korsakova. 2000;100(11):35-7.
[Article in Russian]


Application of ozone therapy was based on the notions of a significant role of lipid peroxidation in the pathogenesis of migraine attacks. A therapy was performed in form of intravenous infusions of the ozonized physiologic solutions with ozone, concentration 1200 micrograms/l; a therapy course included 8-9 procedures. 68 patients with migraine attacks, followed by the pronounced autonomic changes, that developed in the frequency range from 5-6 times a year to 2-3 times a week were examined. 40 patients formed a study group and 28 individuals control one (in a control group the physiologic solution was used without ozone). The intensity of a headache, the expression of an anxiety, the state of the vessels of the brain and some biochemical indices were determined. Positive dynamics of the disease was 25% higher in the study group than made up a those in the controls (p < 0.05). In 58% of the patients the attacks were absent during 3-5 months after ozone therapy; less intensity of headache was observed after their relapse. Improvements in the patients coincides with changes in biochemical parameters.

Publication types

  • English Abstract

MeSH terms

  • Humans
  • Lipid Peroxidation / physiology
  • Migraine Disorders / diagnosis
  • Migraine Disorders / therapy*
  • Ozone / therapeutic use*
  • Severity of Illness Index
  • Treatment Outcome


  • Ozone