Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade

Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1793-801. doi: 10.1152/ajpheart.2001.280.4.H1793.


Our objective was to test the hypothesis that 1) a high Na (HNa, 3%) diet would increase blood pressure (BP) in male Wistar-Kyoto (WKY) and spontaneously hypertensive Y chromosome (SHR/y) rat strains in a territorial colony; 2) sympathetic nervous system (SNS) blockade using clonidine would lower BP on a HNa diet; and 3) prepubertal androgen receptor blockade with flutamide would lower BP on a HNa diet. A 2 x 4 factorial design used rat strains (WKY, SHR/y) and treatment [0.3% normal Na (NNa), 3% HNa, HNa/clonidine, and HNa/flutamide]. BP increased in both strains on the HNa diet (P < 0.0001). There was no significant decrease in BP in either strain with clonidine treatment. Androgen receptor blockade with flutamide significantly decreased BP in both strains (P < 0.0001) and normalized BP in the SHR/y colony. Neither heart rate nor activity could explain these BP differences. In conclusion, a Na sensitivity was observed in both strains, which was reduced to normotensive values by androgen blockade but not by SNS blockade.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Androgen Antagonists / pharmacology*
  • Androgen Receptor Antagonists
  • Animals
  • Blood Pressure / drug effects*
  • Blood Pressure / physiology
  • Clonidine / pharmacology
  • Crosses, Genetic
  • Female
  • Flutamide / pharmacology*
  • Hypertension / genetics
  • Hypertension / physiopathology*
  • Hypertension / prevention & control
  • Male
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Sexual Maturation
  • Sodium, Dietary / pharmacology*
  • Species Specificity
  • Systole
  • Territoriality
  • Y Chromosome


  • Androgen Antagonists
  • Androgen Receptor Antagonists
  • Sodium, Dietary
  • Flutamide
  • Clonidine