Type I collagen degradation does not diminish with RA disease duration

Ann Rheum Dis. 2001 Apr;60(4):420-2. doi: 10.1136/ard.60.4.420.

Abstract

Objective: To assess the relation between type I collagen degradation and the duration of rheumatoid arthritis (RA).

Methods: The serum concentrations of cross linked carboxyterminal telopeptide of type I collagen (ICTP) measured earlier in a community based series (90 patients) and a hospital based series (59 patients) were re-evaluated with reference to the duration of RA.

Results: The serum ICTP showed a positive correlation with the duration of the disease in the hospital based series (r(s)=0.40, p<0.01) but not in the community based one (r(s)=0.18, p=0.10).

Conclusions: Type I collagen degradation predominantly reflecting pathological bone destruction does not seem to diminish in longlasting RA.

MeSH terms

  • Arthritis, Rheumatoid / blood*
  • C-Reactive Protein / analysis
  • Collagen / metabolism*
  • Disease Progression
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peptides / blood
  • Radioimmunoassay
  • Statistics, Nonparametric
  • Time Factors

Substances

  • Peptides
  • Collagen
  • C-Reactive Protein